The Sanctuary of Isis was founded in the 2nd century BCE at Dion, Macedonia, Greece. The cult of Isis at Dion was introduced to Dion during the Hellenistic period (2nd Century BCE), likely replacing or absorbing an older worship of Artemis Lochia (the protector of women in childbirth). The earliest archaeological evidence, including a votive inscription to Isis, Sarapis, and Anubis, dates back to the 2nd century BCE. The sanctuary reached its peak during the Roman Imperial era. Most of the structures currently visible at the archaeological site—including the main temple, the altars, and the various naiskoi (small temples)—were rebuilt or renovated in the 2nd century CE. The site was finally destroyed by an earthquake and subsequent flooding in the late 4th century CE.
Dion Archaeological Park, Macedonia, Greece.